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Related Experiment Video

Updated: Aug 29, 2025

Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation

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Vitamin D and heart failure: A two-sample mendelian randomization study.

Qiang Luo¹, Wei Yan¹, Qiong Nie¹

¹Department of Cardiology, Affiliated Hospital of Southwest Jiaotong University, The Third People's Hospital of Chengdu, 82 Qinglong St. Chengdu, Sichuan, China.

Nutrition, Metabolism, and Cardiovascular Diseases : NMCD

|September 5, 2022

Summary

This summary is machine-generated.

Low vitamin D levels (25-hydroxyvitamin D) are linked to increased heart failure (HF) risk. Maintaining adequate vitamin D may help prevent heart failure.

Keywords:

Causal inference Heart failure Mendelian randomization Vitamin D

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Inverse Probability of Treatment Weighting Propensity Score using the Military Health System Data Repository and National Death Index

Inverse Probability of Treatment Weighting Propensity Score using the Military Health System Data Repository and National Death Index

Published on: January 8, 2020

Area of Science:

Cardiovascular Medicine
Endocrinology
Nutritional Science

Background:

The link between vitamin D and heart failure (HF) is of significant interest but remains uncertain.
Previous studies have yielded conflicting results regarding this association.

Purpose of the Study:

To investigate the potential causal relationship between 25-hydroxyvitamin D (25OHD) levels and the risk of heart failure (HF).
To provide reliable evidence on the association between vitamin D status and HF risk using advanced statistical methods.

Main Methods:

Employed two-sample Mendelian randomization (MR) using large-scale genome-wide association study summary statistics for 25OHD and HF.
Utilized multiple MR methods and multivariable MR adjusting for key comorbidities (hypertension, BMI, diabetes, CKD).
Performed MR analysis with conditionally independent genetic instruments to address potential pleiotropy.

Main Results:

A significant inverse association was found: a 1 SD increase in 25OHD was associated with a 16.5% decreased risk of HF (OR: 0.835, P=0.002).
Consistent results were observed across various MR analyses, including multivariable MR.
Scatter plots indicated a trend towards an inverse association between 25OHD levels and HF risk.

Conclusions:

Elevated 25-hydroxyvitamin D levels are potentially inversely associated with heart failure risk.
Maintaining adequate vitamin D status may be a crucial strategy for preventing heart failure in the general population.