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Monkeypox: disease epidemiology, host immunity and clinical interventions.
Fok-Moon Lum1, Anthony Torres-Ruesta1, Matthew Z Tay1
1A*STAR Infectious Diseases Labs, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.
Nature Reviews. Immunology
|September 6, 2022
Summary
Monkeypox virus (MPXV) outbreaks have emerged globally, with over 48,000 cases and 13 deaths reported. This review covers MPXV
Area of Science:
- * Virology and Epidemiology
- * Infectious Diseases
- * Public Health
Background:
- * Monkeypox virus (MPXV) historically endemic to Africa.
- * Recent unprecedented global outbreaks in non-endemic regions.
- * Rapid increase in MPXV infections worldwide.
Purpose of the Study:
- * To review the clinical, epidemiological, and immunological characteristics of MPXV infections.
- * To identify critical research questions for understanding the current outbreak.
- * To explore new strategies for controlling MPXV spread.
Main Methods:
- * Comprehensive literature review of MPXV.
- * Analysis of clinical case data.
- * Epidemiological trend assessment.
Main Results:
- * Detailed description of MPXV clinical manifestations.
- * Characterization of transmission dynamics in recent outbreaks.
- * Summary of immunological responses to MPXV.
Conclusions:
- * MPXV poses a significant global health threat.
- * Urgent research is needed to address knowledge gaps.
- * Coordinated public health interventions are crucial for outbreak management.
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