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Related Concept Videos

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Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds...
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Updated: Aug 29, 2025

Simultaneous Imaging and Flow-Cytometry-based Detection of Multiple Fluorescent Senescence Markers in Therapy-Induced Senescent Cancer Cells
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Targeting senescence as an anticancer therapy.

Laura Bousset1,2, Jesús Gil1,2

  • 1MRC London Institute of Medical Sciences (LMS), UK.

Molecular Oncology
|September 6, 2022
PubMed
Summary
This summary is machine-generated.

Cellular senescence, a stress response, plays a dual role in cancer. Senolytic drugs targeting senescent cells offer a promising "one-two punch" strategy to enhance cancer therapy by eliminating lingering cells.

Keywords:
cellular senescencechemotherapyoncogene-induced senescenceradiotherapysenolyticstherapy-induced senescence

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Area of Science:

  • Oncology
  • Cell Biology
  • Gerontology

Background:

  • Cellular senescence is a stress-induced cell cycle arrest with phenotypic changes, including a bioactive secretome.
  • Senescent cells accumulate with age and are implicated in aging, fibrosis, and cancer.
  • Senolytics, drugs targeting senescent cells, show therapeutic potential for age-related diseases.

Purpose of the Study:

  • To review the complex relationship between cellular senescence and cancer.
  • To explore how current cancer therapies induce senescence.
  • To discuss the potential of senolytic agents in combination cancer therapy.

Main Methods:

  • Literature review of senescence and cancer.
  • Analysis of senescence induction by anticancer therapies.
  • Evaluation of senolytic strategies in oncology.

Main Results:

  • Senescence can limit cancer progression but also promote it.
  • Anticancer therapies can induce senescence in tumor cells.
  • Senolytics can target senescent tumor cells, complementing conventional treatments.

Conclusions:

  • The interplay between senescence and cancer is intricate and paradoxical.
  • "One-two punch" therapy, combining senescence induction with senolytics, is a promising cancer treatment strategy.
  • Monitoring senescence in patients is crucial for evaluating "one-two punch" therapy efficacy.