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Updated: Aug 29, 2025

Assessment of Cardiac Morphological and Functional Changes in Mouse Model of Transverse Aortic Constriction by Echocardiographic Imaging
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Descending Aortic Distensibility and Cardiovascular Outcomes: A Cardiac Magnetic Resonance Imaging Study

Michael R Sood1,2, Sahar S Abdelmoneim1, Nripen Dontineni1

  • 1Division of Cardiology, New York-Presbyterian Hospital, Brooklyn, NY, USA.

Vascular Health and Risk Management
|September 6, 2022
PubMed

Insights

Aortic distensibility in the descending thoracic aorta is not an independent predictor of cardiovascular outcomes. This study found no significant association after adjusting for other risk factors in patients undergoing cardiovascular magnetic resonance imaging.

Area of Science:

  • Cardiovascular imaging and diagnostics
  • Vascular mechanics and hemodynamics
  • Clinical outcomes research

Background:

  • Aortic distensibility (AD) is crucial for cardiovascular health.
  • Limited data exists on AD in the descending thoracic aorta and its link to cardiovascular outcomes.

Purpose of the Study:

  • To investigate the association between AD measured in the descending thoracic aorta (ADdesc) and major adverse cardiovascular events.
  • To determine if ADdesc is an independent predictor of cardiovascular morbidity and mortality.

Main Methods:

  • A cohort of 928 patients referred for cardiovascular magnetic resonance (CMR) was analyzed.
  • ADdesc was measured using steady-state free precession cine sequences and categorized into quintiles.
  • Cox proportional-hazards regression was used to assess the primary outcome (all-cause mortality, MI, stroke, or revascularization).

Main Results:

  • A decreased ADdesc was associated with traditional cardiovascular risk factors like hypertension and diabetes.
  • Patients with lower ADdesc (≤ median or in the lowest quintile) had a higher incidence of the primary outcome.
  • However, ADdesc was not an independent predictor of the primary endpoint after multivariable adjustment.

Conclusions:

  • In a real-world CMR cohort, ADdesc is not an independent predictor of cardiovascular outcomes.
  • Further research may be needed to clarify the role of descending thoracic aorta distensibility in cardiovascular risk stratification.
Abstract

Keywords:
ADCMRaortic distensibilitycardiovascular magnetic resonancedescending aorta

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