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CYP2C8*3 and *4 define CYP2C8 phenotype: An approach with the substrate cinitapride

Diana María Campodónico1, Pablo Zubiaur1,2, Paula Soria-Chacartegui1

  • 1Clinical Pharmacology Department, Instituto Teófilo Hernando, Instituto de Investigación Sanitaria La Princesa (IP), Hospital Universitario de La Princesa, Universidad Autónoma de Madrid (UAM), Madrid, Spain.

Clinical and Translational Science
|September 6, 2022
PubMed
Summary

Genetic variants in CYP2C8 significantly impact cinitapride drug levels. Specific CYP2C8 alleles influence cinitapride pharmacokinetics, affecting drug metabolism and potentially patient response.

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