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Updated: Aug 29, 2025

Author Spotlight: Advancements in Multiplex Detection of Respiratory Viruses
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Multisystem involvement in COVID-19: what have we learnt?

Kenneth Mangion1,2,3, Colin Berry1,2,3

  • 1British Heart Foundation Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.

British Journal of Hospital Medicine (London, England : 2005)
|September 6, 2022
PubMed
Summary

Long COVID is linked to multisystem disease, affecting quality of life and physical and psychological wellbeing. Hospital physicians should consider myocarditis in patients with post-COVID-19 syndrome due to persistent inflammation.

Keywords:
COVID-19Multi-system involvementMyocardial inflammationMyocarditisPost-COVID-19 syndromeSARS-CoV-2

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Area of Science:

  • Cardiology
  • Nephrology
  • Pulmonology
  • Infectious Diseases

Background:

  • COVID-19 can lead to persistent inflammation affecting multiple organ systems.
  • Post-COVID-19 syndrome, or long COVID, is associated with lingering impairments.
  • Multisystem disease may explain long-term patient-reported issues.

Purpose of the Study:

  • To explore the link between post-COVID-19 syndrome and multisystem disease.
  • To inform hospital physicians about myocarditis risk in long COVID patients.
  • To discuss long-term implications of cardiac involvement in post-COVID-19 syndrome.

Main Methods:

  • The study analyzed the trajectory of COVID-19 illness.
  • Researchers investigated the connection between long COVID and multisystem disease.
  • The authors' team conducted observational analysis.

Main Results:

  • A link was found between post-COVID-19 syndrome and multisystem disease.
  • This multisystem involvement partly explains impaired quality of life, physical function, and psychological wellbeing.
  • Persistent cardio-renal inflammation and lung involvement are key features of COVID-19's trajectory.

Conclusions:

  • Post-COVID-19 syndrome is characterized by multisystem disease, impacting patient recovery.
  • Hospital physicians must consider myocarditis in patients presenting with post-COVID-19 syndrome.
  • Understanding the long-term implications of cardiac inflammation is crucial for patient management.