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Related Concept Videos

Pulse rhythm01:30

Pulse rhythm

907
Pulse rhythm refers to the pattern of pulsations within specific intervals, offering valuable insights into the regularity or irregularity of the heart's beats as observed through the pattern of pulsation within specific intervals. A regular pulse exhibits a consistent heart rate with uniform waveforms and pulsation force, variations of which can be classified as normal, weak, or bounding.
Conversely, an irregular pulse pattern is termed dysrhythmia, stemming from disruptions in cardiac...
907

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Related Experiment Video

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In Vitro Thrombosis Test for Ventricular Assist Devices
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Improved Detection Of Thromboembolic Complications In Left Ventricular Assist Device By Novel Accelerometer-Based

Itai Schalit1,2,3, Andreas Espinoza1,2, Fred-Johan Pettersen4

  • 1From the The Intervention Centre, Oslo University Hospital.

ASAIO Journal (American Society for Artificial Internal Organs : 1992)
|September 6, 2022
PubMed
Summary

Nonharmonic-amplitude (NHA) analysis improves the detection of thromboembolism and pump thrombosis in HeartWare Left Ventricular Assist Devices (HVAD). Combining NHA with third-harmonic frequency analysis significantly enhances diagnostic accuracy for these critical complications.

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Area of Science:

  • Biomedical Engineering
  • Cardiovascular Devices
  • Vibration Analysis

Background:

  • Accelerometer-based vibration analysis, specifically the third harmonic frequency (pump_speedx3), has been shown to detect thromboembolism and pump thrombosis in HeartWare Left Ventricular Assist Devices (HVAD).
  • Thromboembolic events also influence nonharmonic frequencies, suggesting their potential diagnostic utility.

Purpose of the Study:

  • To evaluate whether nonharmonic-amplitude (NHA) analysis can enhance the diagnosis of thromboembolic complications in HVAD.
  • To determine the combined diagnostic performance of NHA and third-harmonic frequency analysis.

Main Methods:

  • An accelerometer was attached to HVAD in vitro and in vivo experiments.
  • Sliding fast-Fourier-transform analysis was used to quantify changes in NHAs during control interventions and following thromboembolic events.
  • Receiver operating characteristic curves and positive predictive values (PPV) were calculated to assess diagnostic accuracy.

Main Results:

  • In the acute phase, NHA change was significantly higher during thromboembolism compared to control interventions (6.5-fold increase, p < 0.001).
  • Combining NHA with third-harmonic amplitude analysis improved PPV by 8.3% in the acute phase and by 36% in the steady state.
  • Most thromboembolic events caused changes in both NHA and third-harmonic amplitude.

Conclusions:

  • Nonharmonic-amplitude (NHA) analysis is a valuable method for improving the detection of thromboembolic complications in HVAD.
  • The combined analysis of NHA and third-harmonic frequency offers a significantly enhanced diagnostic capability for thromboembolism and pump thrombosis in HVAD.