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Updated: Aug 29, 2025

Dural Stimulation and Periorbital von Frey Testing in Mice As a Preclinical Model of Headache
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Dermatologic Symptoms and Syndromes Associated with Headache.

Arathi Nandyala1, Carrie Dougherty2

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|September 6, 2022
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Summary

Headache disorders can manifest with skin changes like rashes and bruising. This review explores the link between dermatologic conditions and headache, aiding diagnosis and management.

Keywords:
EcchymosisHeadacheMigraineNeurofibromatosisParry-Romberg syndromePsoriasisRosaceaSturge-Weber syndrome

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Area of Science:

  • Neurology
  • Dermatology

Background:

  • Headache disorders frequently involve symptoms beyond the nervous system.
  • Skin conditions are not typically considered common headache comorbidities.

Purpose of the Study:

  • To review dermatologic presentations associated with headache disorders.
  • To aid in the workup and management of headaches in patients with skin conditions.

Main Methods:

  • Review of multiple articles and retrospective studies.
  • Categorization of dermatologic presentations into ecchymoses, inflammatory skin conditions, and neurocutaneous disorders.

Main Results:

  • Established association between head pain and dermatologic changes like ecchymoses, rashes, and neurocutaneous disorders.
  • Postulated mechanisms involve trigeminal autonomic system activation and shared inflammatory pathways.

Conclusions:

  • Dermatologic manifestations can be linked to headache disorders.
  • Understanding these associations can guide clinical evaluation and treatment strategies.