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[Synthesis, cloning and primary structure of DNA complementary to mRNA for human pituitary pro-opiomelanocortin]

S Ia Golovin, V A Karginov, A A Bondar'

    Bioorganicheskaia Khimiia
    |April 1, 1987
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    Transcription02:09

    Transcription

    Transcription is the process of synthesizing RNA from a DNA sequence by RNA polymerase. It is the first step in producing a protein from a gene sequence. Additionally, many other proteins and regulatory sequences are involved in the proper synthesis of messenger RNA (mRNA). Regulation of transcription is responsible for the differentiation of all the different types of cells and often for the proper cellular response to environmental signals.Transcription Can Produce Different Kinds of RNA...
    The Central Dogma01:25

    The Central Dogma

    Overview
    Complementary DNA02:25

    Complementary DNA

    Only genes that are transcribed into messenger RNA (mRNA) are active, or expressed. Scientists can, therefore, extract the mRNA from cells to study gene expression in different cells and tissues. The scientist converts mRNA into complementary DNA (cDNA) via reverse transcription. Because mRNA does not contain introns (non-coding regions) and other regulatory sequences, cDNA—unlike genomic DNA—also allows researchers to directly determine the amino acid sequence of the peptide encoded by the...
    Complementary DNA02:25

    Complementary DNA

    Only genes that are transcribed into messenger RNA (mRNA) are active, or expressed. Scientists can, therefore, extract the mRNA from cells to study gene expression in different cells and tissues. The scientist converts mRNA into complementary DNA (cDNA) via reverse transcription. Because mRNA does not contain introns (non-coding regions) and other regulatory sequences, cDNA—unlike genomic DNA—also allows researchers to directly determine the amino acid sequence of the peptide encoded by the...
    The Central Dogma01:20

    The Central Dogma

    The central dogma explains the flow of genetic information from DNA nucleotides to the amino acid sequence of proteins.
    RNA is the Missing Link Between DNA and Proteins
    In the early 1900s, scientists discovered that DNA stores all the information needed for cellular functions and that proteins perform most of these functions. However, the mechanisms of converting genetic information into functional proteins remained unknown for many years. Initially, it was believed that a single gene is...
    Transcription01:17

    Transcription

    Transcription is the synthesis of RNA from a DNA sequence by RNA polymerase. It is the first step in producing a protein from a gene sequence. Additionally, many other proteins and regulatory sequences are involved in correctly synthesizing messenger RNA (mRNA). Transcriptional regulation is responsible for the differentiation of different types of cells and often for the proper cellular response to environmental signals.
    Transcription Can Produce Different Kinds of RNA Molecules
    In eukaryotes,...