Resveratrol Treatment of Autism Spectrum Disorder-A Pilot Study

Area of Science:

• Neuroscience
• Immunology
• Pediatrics

Background:

• Autism spectrum disorder (ASD) is a neurodevelopmental condition often linked to immune system impairments.
• Trans-resveratrol (RSV) possesses anti-inflammatory, antioxidant, and neuroprotective properties.
• Investigating novel therapeutic strategies for ASD behavioral and molecular aspects is crucial.

Purpose of the Study:

• To evaluate the efficacy, tolerability, and safety of trans-resveratrol (RSV) in pediatric subjects with ASD.
• To assess RSV's impact on behavioral impairments and specific immune-related microRNAs (miRNAs) in children with ASD.

Main Methods:

• An open-label pilot trial was conducted over 90 days.
• Five boys aged 10-13 years diagnosed with ASD received 200 mg/day of RSV.
• Behavioral assessments (Aberrant Behavior Checklist, Clinical Global Impression) and miRNA analysis were performed.

Main Results:

• RSV significantly reduced the Aberrant Behavior Checklist total score and Irritability subscale (P=0.042, P=0.041).
• Three participants showed marked behavioral improvement on the Clinical Global Impression scale.
• RSV increased miR-195-5p levels (P=0.043), a key modulator of inflammatory and immunological pathways, with no adverse effects.

Conclusions:

• Trans-resveratrol (RSV) is a safe molecule for pediatric administration in ASD.
• RSV demonstrates potential in modulating behavioral alterations and immune-related molecules in children with ASD.
• Further large-scale studies are warranted to explore RSV as a therapeutic strategy for ASD.