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Related Experiment Video

Updated: Aug 29, 2025

Author Spotlight: Development of a Scaffold-Free Acoustic Assembly Method for High-Quality 3D Cell Spheroid Culture
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Surface-Acoustic-Wave (SAW)-Driven Device for Three-Dimensional Cell Manipulation.

Zenan Wang, Jie Tao, Jun Tian

    IEEE Transactions on Bio-Medical Engineering
    |September 6, 2022
    PubMed
    Summary
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    This study introduces a novel noninvasive cell orientation system using surface acoustic waves (SAWs). The system efficiently rotates cytoplasm for improved cell manipulation outcomes.

    Area of Science:

    • Biotechnology
    • Cell Biology
    • Acoustics

    Background:

    • Cell orientation is critical for micromanipulation, but current methods are inefficient, invasive, or complex.
    • Existing techniques like manual manipulation, mechanical contact, and other non-contact methods have significant limitations.

    Purpose of the Study:

    • To develop a noninvasive cell orientation system using surface acoustic waves (SAWs).
    • To enable precise rotation of cellular components without compromising cell integrity.

    Main Methods:

    • Utilized a SAW chip with interdigital transducers (IDTs) to generate acoustic streaming force.
    • Developed a system to rotate cytoplasm through the cell chorion, targeting X and Y axes.
    • Integrated cellular structure recognition for visual feedback and precise rotation control.

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    Manipulating Living Cells to Construct Stable 3D Cellular Assembly Without Artificial Scaffold
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    Related Experiment Videos

    Last Updated: Aug 29, 2025

    Author Spotlight: Development of a Scaffold-Free Acoustic Assembly Method for High-Quality 3D Cell Spheroid Culture
    05:17

    Author Spotlight: Development of a Scaffold-Free Acoustic Assembly Method for High-Quality 3D Cell Spheroid Culture

    Published on: October 13, 2023

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    Microparticle Manipulation by Standing Surface Acoustic Waves with Dual-frequency Excitations
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    Manipulating Living Cells to Construct Stable 3D Cellular Assembly Without Artificial Scaffold
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    Manipulating Living Cells to Construct Stable 3D Cellular Assembly Without Artificial Scaffold

    Published on: October 26, 2018

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    Main Results:

    • Successfully recognized all cellular structures required for visual feedback in 100 embryo images.
    • Achieved precise cell rotation with an orientation angle error of less than 4° in 26 cases within 10 seconds.
    • Demonstrated noninvasive manipulation with all 30 zebrafish embryos hatching post-procedure.

    Conclusions:

    • The proposed SAW-based system offers an automated, noninvasive method for cell orientation.
    • This technique allows for precise rotation of cytoplasm through the cell chorion.