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Brain morphometry changes with fatigue severity in fibromyalgia.

Hung-Yu Liu1, Pei-Lin Lee2, Kun-Hsien Chou3

  • 1Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, and School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.

Clinical and Experimental Rheumatology
|September 6, 2022
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Summary
This summary is machine-generated.

Brain changes in fibromyalgia (FM) are linked to fatigue severity. Decreased thalamic volume and altered temporal cortex structure are associated with increased fatigue, suggesting potential therapeutic targets.

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Area of Science:

  • Neuroimaging
  • Clinical Neuroscience
  • Medical Imaging

Background:

  • Fibromyalgia (FM) is a chronic condition characterized by widespread pain and fatigue.
  • Fatigue severity in FM is a significant factor impacting patient quality of life.
  • Understanding the neurobiological underpinnings of fatigue in FM is crucial for developing effective treatments.

Purpose of the Study:

  • To investigate brain morphometry changes associated with varying levels of fatigue severity in patients with fibromyalgia.
  • To identify specific brain regions and structural covariance networks that correlate with fatigue severity in FM.

Main Methods:

  • Voxel-based morphometry and trend analysis were employed on MRI data from 138 FM patients.
  • Patients were categorized into mild, moderate, and severe fatigue groups.
  • Structural covariance (SC) networks were analyzed to assess connectivity patterns.

Main Results:

  • Decreased bilateral thalamic volumes were significantly associated with higher fatigue severity, even after adjusting for anxiety and depression.
  • Increased right inferior temporal cortex volumes correlated with increased fatigue severity.
  • Structural covariance analysis revealed widespread thalamic network alterations and specific temporal/occipital connectivity changes in severe fatigue groups.

Conclusions:

  • The thalamus and right inferior temporal cortex play a role in the manifestation of fatigue severity in fibromyalgia.
  • These identified brain regions represent potential targets for future therapeutic interventions aimed at alleviating fatigue in FM.