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Murine Distal Colostomy, A Novel Model of Diversion Colitis in C57BL/6 Mice
Published on: July 12, 2018
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Progression of ulcerative colitis following diversion colitis
Katsuki Yaguchi1,2, Yusuke Matsune1, Reiko Kunisaki3,4
1Inflammatory Bowel Disease Center, Yokohama City University Medical Center, 4-57 Urafune-cho Minami-ku, Yokohama, 232-0024, Japan.
Clinical Journal of Gastroenterology
|September 6, 2022
Summary
A rare case shows diversion colitis may trigger ulcerative colitis (UC) development. This highlights potential immune responses in the gut following surgical diversions.
Area of Science:
- Gastroenterology
- Colorectal Surgery
- Immunology
Background:
- Diversion colitis and ulcerative colitis (UC) are distinct inflammatory bowel conditions.
- Several case reports suggest a potential link between diversion colitis and the subsequent development of UC.
Observation:
- A 63-year-old male developed diversion colitis in a surgically created blind sigmoid colon segment after Hartmann's operation.
- Following stoma closure, symptoms of bloody stools (hematochezia) initially improved with topical mesalazine but recurred.
- Colonoscopy revealed characteristic inflammation in both the rectal and blind sigmoid colon segments.
Findings:
- Histological examination of the affected colon segments showed basal plasmacytosis, goblet cell depletion, and cryptitis.
- These findings are histologically characteristic of ulcerative colitis (UC).
- This represents the fourth reported case of UC developing subsequent to diversion colitis.
Implications:
- The study suggests that local inflammation from diversion colitis may trigger the development of UC.
- Potential mechanisms include hematogenous or lymphogenous spread of lymphocytes or autoantibodies.
- This case underscores the importance of monitoring for UC development in patients with a history of diversion colitis.
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