Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Factors Affecting Drug Response: Overview01:21

Factors Affecting Drug Response: Overview

2.1K
When it comes to infants and young children, they are typically administered smaller doses of medication in comparison to adults. This is primarily because their organ functions still need to fully develop, meaning their bodies are not as efficient at metabolizing or eliminating drugs. Additionally, their blood-brain barrier is more permeable than in adults. As a result, high concentrations of drugs can easily penetrate the central nervous system (CNS), potentially leading to neurological...
2.1K
Human Genetics01:28

Human Genetics

692
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
692
Analysis of Population Pharmacokinetic Data01:12

Analysis of Population Pharmacokinetic Data

363
Analysis of population pharmacokinetic data involves studying the behavior of drugs within diverse populations to understand their pharmacokinetic parameters. Traditional pharmacokinetic methods typically involve collecting samples from a few individuals and estimating these parameters. While these methods are commonly used, they have limitations in capturing the variability in drug response among individuals or heterogeneous populations. Population pharmacokinetics is employed to address these...
363
Pharmacokinetic Models: Comparison and Selection Criterion01:26

Pharmacokinetic Models: Comparison and Selection Criterion

134
Physiological and compartmental models are valuable tools used in studying biological systems. These models rely on differential equations to maintain mass balance within the system, ensuring an accurate representation of the dynamic processes at play.
Physiological models take a detailed approach by considering specific molecular processes. They can predict drug distribution, metabolism, and elimination changes, providing a comprehensive understanding of how drugs interact with the body.
134
Pharmacokinetic Models: Overview01:20

Pharmacokinetic Models: Overview

1.0K
Pharmacokinetic models utilize mathematical analysis to achieve a detailed quantitative understanding of a drug's life cycle within the body. They are instrumental in simulating a drug's pharmacokinetic parameters, predicting drug concentrations over time, optimizing dosage regimens, linking concentrations with pharmacologic activity, and estimating potential toxicity.
There are three primary types of models: empirical, compartment, and physiological. Empirical models, with minimal...
1.0K
Nonlinear Pharmacokinetics: Dependence of Elimination Half-Life and Dose Clearance01:23

Nonlinear Pharmacokinetics: Dependence of Elimination Half-Life and Dose Clearance

282
The elimination half-life and drug clearance of drugs following nonlinear kinetics can vary with dosage. The Michaelis-Menten parameters and drug concentration influence these factors. As the dose increases, the elimination half-life tends to lengthen, resulting in a reduction in clearance and a disproportionately larger area under the curve. The total clearance can be derived from the Michaelis-Menten equation for drugs following a one-compartment model.
A study on guinea pigs examined the...
282

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Systematic Review and Meta-Analysis of the Effectiveness of Process Interventions for Reducing Distress during Vaccine Injections.

The Clinical journal of pain·2026
Same author

Oral morphine pharmacokinetics in healthy children and the effect of genetic polymorphisms: An exploratory study.

Paediatrics & child health·2026
Same author

Longitudinal assessment of changes in hair cortisol levels and associations with violence, poor mental health and harmful substance use among female sex workers in Nairobi, Kenya.

PLOS global public health·2026
Same author

Body mass index associated with glucocorticoid-related weight gain in children with rheumatic disease on high-dose prednisone.

Clinical and experimental rheumatology·2025
Same author

Trimethoprim-Sulfamethoxazole and Acute Respiratory Failure in Adolescents and Young Adults.

JAMA network open·2025
Same author

Exploring the landscape of pharmacology education in Health Professions Programs: From historical perspectives to current approaches to teaching.

European journal of pharmacology·2025

Related Experiment Video

Updated: Aug 29, 2025

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
05:53

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

10.2K

Pharmacogenomics in Children.

Michael J Rieder1, Abdelbaset A Elzagallaai2

  • 1Division of Paediatric Clinical Pharmacology, Department of Paediatrics, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada. mrieder@uwo.ca.

Methods in Molecular Biology (Clifton, N.J.)
|September 6, 2022
PubMed
Summary
This summary is machine-generated.

Genetics significantly impacts children's disease and drug responses. Pharmacogenomic assessment is becoming more feasible and crucial for pediatric treatment decisions, especially in childhood cancer.

Keywords:
Childhood cancerChildrenDrug ontogenyDrug safetyGeneticsPharmacogenomicsPharmacology

More Related Videos

In Vivo Modeling of the Morbid Human Genome using Danio rerio
12:31

In Vivo Modeling of the Morbid Human Genome using Danio rerio

Published on: August 24, 2013

20.8K
Author Spotlight: Genetic Profiling for Fluorouracil Response in Gastric Cancer
06:21

Author Spotlight: Genetic Profiling for Fluorouracil Response in Gastric Cancer

Published on: May 10, 2024

831

Related Experiment Videos

Last Updated: Aug 29, 2025

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
05:53

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

10.2K
In Vivo Modeling of the Morbid Human Genome using Danio rerio
12:31

In Vivo Modeling of the Morbid Human Genome using Danio rerio

Published on: August 24, 2013

20.8K
Author Spotlight: Genetic Profiling for Fluorouracil Response in Gastric Cancer
06:21

Author Spotlight: Genetic Profiling for Fluorouracil Response in Gastric Cancer

Published on: May 10, 2024

831

Area of Science:

  • Pediatric pharmacology
  • Genetics and genomics
  • Translational medicine

Background:

  • Historically, genetic factors were overlooked in pediatric drug prescription.
  • Genetics plays a key role in both disease susceptibility and drug response in children.
  • Recent advancements facilitate pharmacogenomic assessments in pediatric populations.

Purpose of the Study:

  • To highlight the importance of genetics in pediatric drug therapy.
  • To discuss the growing feasibility of pharmacogenomic assessment in children.
  • To emphasize the potential integration of pharmacogenomics into pediatric clinical practice.

Main Methods:

  • Review of historical practices in pediatric drug prescribing.
  • Analysis of current advancements in pediatric research ethics and therapy.
  • Discussion of the role of genetics in drug efficacy and safety for children.

Main Results:

  • Genetics is a critical determinant of disease and drug response in pediatric populations.
  • Pharmacogenomic assessment in children is increasingly practical due to therapeutic and ethical advances.
  • Pharmacogenomics holds significant promise for optimizing pediatric treatment.

Conclusions:

  • Genetics is fundamental to understanding pediatric disease and drug response.
  • Pharmacogenomic approaches are essential for personalized pediatric medicine.
  • The integration of pharmacogenomics into pediatric care, particularly for conditions like childhood cancer, is a critical future direction.