Diagnostic biomolecules and combination therapy for pre-eclampsia

Area of Science:

• Obstetrics and Gynecology
• Perinatal Medicine
• Biochemical Diagnostics

Background:

• Pre-eclampsia (PE) is a leading cause of maternal and perinatal mortality, linked to placental malperfusion and endothelial injury.
• Current diagnostic methods for PE, including maternal characteristics and biophysical markers, have limitations in precision.
• No pharmaceutical intervention currently halts PE progression, emphasizing the need for early diagnosis and management.

Purpose of the Study:

• To review advancements in biochemical prediction of pre-eclampsia.
• To explore interventions aimed at ameliorating PE disease progression.
• To provide references for improved clinical diagnosis and treatment of PE.

Main Methods:

• Literature review focusing on biochemical factors in PE development.
• Analysis of current diagnostic targets based on PE pathogenesis and molecular phenotypes.
• Examination of interventions associated with biochemical markers for PE.

Main Results:

• Biochemical factor research has identified potential diagnostic targets for PE.
• Early and precise diagnosis of PE can optimize outcomes through expectant management.
• Developments in biochemical prediction offer new avenues for clinical application.

Conclusions:

• Enhanced biochemical prediction of PE is critical for timely intervention.
• Targeted interventions based on biochemical markers may improve maternal and fetal outcomes.
• Further research is needed to translate biochemical findings into effective clinical practice for PE management.