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Published on: May 16, 2013
Increased circulating myeloid-derived suppressor cells in vivax malaria and severe falciparum malaria
Leo Leonardo1, Enny Kenangalem1, Jeanne R Poespoprodjo1,2
1Papuan Health and Community Development Foundation, Timika, Papua, Indonesia.
Background:
Circulating myeloid-derived-suppressor-cells (MDSC) with immunosuppressive function are increased in human experimental Plasmodium falciparum infection, but have not been studied in clinical malaria.
Methods:
Using flow-cytometry, circulating polymorphonuclear-MDSC were evaluated in cryopreserved samples from patients with uncomplicated Plasmodium vivax (n = 8) and uncomplicated (n = 4) and severe (n = 16) falciparum malaria from Papua, Indonesia.
Results:
The absolute number of circulating polymorphonuclear-MDSC were significantly elevated in severe falciparum malaria patients compared to controls (n = 10). Polymorphonuclear-MDSC levels in uncomplicated vivax malaria were also elevated to levels comparable to that seen in severe falciparum malaria.
Conclusion:
Control of expansion of immunosuppressive MDSC may be important for development of effective immune responses in falciparum and vivax malaria.
