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Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...

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The current status and future prospects for molecular imaging-guided precision surgery.

Imke Boekestijn^1,2, Matthias N van Oosterom¹, Paolo Dell'Oglio^1,3

¹Interventional Molecular Imaging Laboratory, Department of Radiology, Leiden University Medical Center, Leiden, the Netherlands.

Cancer Imaging : the Official Publication of the International Cancer Imaging Society

|September 6, 2022

Summary

Molecular imaging enhances precision surgery by improving visualization of cancer targets. This technology guides surgeons to accurately identify and treat both small and large tumors, leading to better patient outcomes.

Keywords:

Digital surgery Fluorescence imaging Image-guided therapy Intraoperative molecular imaging Multimodal imaging Pharmacokinetics Surgery Surgical navigation

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Area of Science:

Oncology
Surgical Technology
Medical Imaging

Background:

Molecular imaging is crucial for cancer diagnosis, monitoring, and treatment guidance.
Precision surgery relies on accurate visualization of surgical targets.

Purpose of the Study:

To review the current status and future of molecular imaging in precision surgery.
To discuss the core components of intraoperative molecular imaging.

Main Methods:

Review of molecular imaging technologies and their application in surgery.
Focus on imaging agents, modalities, and engineering advancements.
Integration of digital surgery tools like computer-aided visualization.

Main Results:

Effective intraoperative molecular imaging requires relevant, accessible targets and optimized imaging agents/modalities.
Advancements in imaging physics enhance sensitivity, contrast, and spatial resolution for detecting cancer.
Digital surgery complements imaging by linking planning with execution.

Conclusions:

Molecular imaging is a key instrument for advancing precision surgery in oncology.
Continued development in imaging and digital technologies is vital for improving surgical performance and patient outcomes.
Objective evaluation mechanisms are needed to assess the impact of these technologies.