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Simultaneous affinity maturation and developability enhancement using natural liability-free CDRs

Andre A R Teixeira1, Sara D'Angelo2, M Frank Erasmus2

  • 1New Mexico Consortium, Los Alamos, NM, USA.

Mabs
|September 7, 2022
PubMed
Abstract

Abbreviations:

CDR: complementarity determining region; FACS: fluorescence-activated cell sorting; ka: association rate; kd: dissociation rate; KD: dissociation constant; scFv: single-chain variable fragment; SPR: surface plasmon resonance.

Keywords:
Affinity maturationCDR shufflingdevelopabilityliabilitylibrary constructionoff-ratescFv

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