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Positron Emission Tomography

Positron Emission Tomography

Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body...

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Related Experiment Video

Updated: Aug 29, 2025

Semi-quantitative Assessment Using [18F]FDG Tracer in Patients with Severe Brain Injury

Semi-quantitative Assessment Using [18F]FDG Tracer in Patients with Severe Brain Injury

Published on: November 9, 2018

Dynamic FDG-PET demonstration of functional brain abnormalities.

Mark Quigg¹, Bijoy Kundu²

¹Department of Neurology, University of Virginia, Charlottesville, Virginia, 22908, USA.

Annals of Clinical and Translational Neurology

|September 7, 2022

Summary

Dynamic PET offers improved brain metabolic mapping over traditional 18F-FDG-PET scans. This advanced technique quantifies tracer uptake dynamics for better differentiation of normal versus pathological brain tissue in disorders like tumors and epilepsy.

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Semi-quantitative Assessment Using [18F]FDG Tracer in Patients with Severe Brain Injury

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Radiotracer Administration for High Temporal Resolution Positron Emission Tomography of the Human Brain: Application to FDG-fPET

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Studying Metabolic Brain Connectivity Using 2-Deoxy-2-[18F]Fluoro-D-Glucose Dynamic Positron Emission Tomography at the Single-subject Level

Studying Metabolic Brain Connectivity Using 2-Deoxy-2-[¹⁸F]Fluoro-D-Glucose Dynamic Positron Emission Tomography at the Single-subject Level

Published on: January 24, 2025

Area of Science:

Neuroimaging
Nuclear Medicine
Biophysics

Background:

Fluorine-18 fluorodeoxyglucose Positron Emission Tomography (18F-FDG-PET) has been a cornerstone for over 30 years in mapping brain glucose metabolism.
Traditional PET's absolute uptake quantification shows limitations in distinguishing normal from pathological brain tissue, particularly in conditions like brain neoplasms and focal epilepsy.
These limitations necessitate the development of advanced imaging techniques for more precise functional mapping.

Purpose of the Study:

To introduce and review dynamic PET as an alternative metabolic mapping process.
To highlight the advantages of dynamic PET in quantifying tracer uptake and decay dynamics.
To explore the potential of dynamic PET for enhanced functional mapping of brain metabolic activity.

Main Methods:

Review of dynamic Positron Emission Tomography (PET) principles and technical implementation.
Analysis of findings from initial pilot studies utilizing dynamic PET.
Comparison of dynamic PET with traditional 18F-FDG-PET for metabolic mapping.

Main Results:

Dynamic PET quantifies the temporal changes in tracer uptake and clearance, offering a more detailed metabolic profile.
Pilot studies suggest dynamic PET can improve the resolution between normal and pathological tissues in brain tumors and epilepsy.
This enhanced resolution aids in more accurate surgical planning and treatment monitoring.

Conclusions:

Dynamic PET represents a significant advancement in brain metabolic imaging, overcoming limitations of traditional methods.
The quantification of tracer kinetics provides superior functional mapping for neurological disorders.
Further research and clinical implementation of dynamic PET hold promise for improved diagnosis and management of brain conditions.