What's new in kidney tumor pathology 2022: WHO 5th edition updates

Area of Science:

• Uropathology
• Oncology
• Genitourinary Pathology

Background:

• The World Health Organization (WHO) Classification of Urinary and Male Genital Tumours is a critical resource for diagnosing and managing these cancers.
• The 5th edition (2022) represents a substantial update, particularly impacting the classification of renal cell tumors.

Purpose of the Study:

• To summarize the most significant diagnostic updates from the 5th edition WHO Classification of Urinary and Male Genital Tumours (2022).
• To focus on the restructured renal cell tumor chapters, including known, new, and emerging entities.

Main Methods:

• Review of the 5th edition (2022) WHO Classification of Urinary and Male Genital Tumours.
• Identification and synthesis of key changes in renal cell tumor classification.
• Highlighting diagnostic criteria for known, new, and provisional kidney tumor entities.

Main Results:

• The 5th edition WHO Classification (2022) features a significantly restructured approach to renal cell tumors.
• Key updates include the recognition of new molecularly defined entities and provisional classifications.
• Diagnostic criteria for established kidney tumor types have been refined.

Conclusions:

• The 2022 WHO Classification necessitates updated diagnostic approaches for urinary and male genital tumors, especially renal cell tumors.
• Understanding these changes is crucial for accurate diagnosis, treatment, and patient management in daily practice.