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Updated: Aug 29, 2025
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Synthesis and Calibration of Phosphorescent Nanoprobes for Oxygen Imaging in Biological Systems
Published on: March 3, 2010
14.0K
Dual-mode nanophotonic upconversion oxygen sensors.
Esmaeil Heydari1,2, Javad AmirAhmadi1, Nahid Ghazyani1
1Faculty of Physics, Kharazmi University, Tehran, 15719-14911, Iran. e.heydari@khu.ac.ir.
Nanoscale
|September 7, 2022
Summary
This study presents a novel nanophotonic biosensor for real-time oxygen detection using near-infrared excitation. The developed sensor demonstrates enhanced sensitivity and performance, paving the way for implantable oxygen monitoring platforms.
Area of Science:
- Nanophotonics
- Biosensing
- Materials Science
Background:
- Near-infrared (NIR) excitable nanophotonic biosensors offer versatile applications.
- Real-time oxygen detection is crucial in various scientific and medical fields.
Purpose of the Study:
- To develop a 980 nm-excitable nanophotonic sensor for oxygen detection in water and air.
- To investigate the enhanced oxygen sensitivity and performance of the developed sensor.
Main Methods:
- Utilized a nanocomposite of lanthanide-doped NaYF4:Yb3+,Tm3+ upconversion nanoparticles and PtTFPP platinum porphyrin in a polystyrene matrix.
- Analyzed photoluminescence (PL) lifetime and intensity for oxygen sensing.
- Evaluated sensor performance including sensitivity, stability, reversibility, and temperature dependence.
Main Results:
- Achieved 68% efficient excitation of PtTFPP using a 980 nm NIR laser.
- Demonstrated over a 10-fold boost in PL lifetime-based oxygen sensitivity by incorporating PtTFPP.
- Showcased amplified PL intensity (>12 times) under skin using 980 nm excitation compared to 410 nm.
Conclusions:
- The developed nanophotonic sensor enables efficient real-time oxygen detection with enhanced sensitivity.
- The 980 nm excitation offers superior performance, particularly for in-vivo applications.
- This technology holds promise for developing advanced implantable oxygen sensor platforms.
