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Updated: Aug 29, 2025

Palladium N-Heterocyclic Carbene Complexes: Synthesis from Benzimidazolium Salts and Catalytic Activity in Carbon-carbon Bond-forming Reactions
Published on: July 30, 2017
Electrochemical Amidation: Benzoyl Hydrazine/Carbazate and Amine as Coupling Partners
Tipu Alam1, Amitava Rakshit1, Hirendra Nath Dhara1
1Department of Chemistry, Indian Institute of Technology Guwahati, North Guwahati 781039, India.
Abstract:
An electrochemical amidation of benzoyl hydrazine/carbazate and primary/secondary amine as coupling partners via concomitant cleavage and formation of C(sp2)-N bonds has been achieved. This methodology proceeds under metal-free and exogenous oxidant-free conditions producing N2 and H2 as byproducts. Mechanistic studies reveal the in situ generations of both acyl and N-centered radicals from benzoyl hydrazines and amines. The utility of this protocol is demonstrated through a large-scale, and synthesis of bezafibrate, a hyperlipidemic drug.
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