Related Experiment Video
Updated: Aug 29, 2025

Development of Heterogeneous Enantioselective Catalysts using Chiral Metal-Organic Frameworks MOFs
Published on: January 17, 2020
A review on chiral metal-organic frameworks: synthesis and asymmetric applications
Mingxuan Ma1, Jiahuan Chen1, Hongyu Liu1
1Department of Pharmacy, The Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, Jiangsu Province 225000, People's Republic of China. feebyxuyuan@163.com.
Abstract:
Chiral metal-organic frameworks (CMOFs) have the characteristics of framework structure diversity and functional tunability, and have important applications in the fields of chiral identification, separation of enantiomers and asymmetric catalysis. In recent years, the application of CMOFs has also been extended to other research fields, such as circularly polarized fluorescence and chiral ferroelectrics. Compared with achiral MOFs, the design of CMOFs only considers the modes of introduction of chirality, and also takes into account the crystallization and purification. Therefore, the synthesis and characterization of CMOFs face many difficult challenges. This review discusses three effective strategies for constructing CMOFs, including direct synthesis of chiral ligands, spontaneous resolution of achiral ligands or chiral template-induced synthesis, and post-synthetic chiralization of achiral MOFs. In addition, this review also discusses the recent application progress of CMOFs in chiral molecular recognition, enantiomer separation, asymmetric catalysis, circularly polarized fluorescence, and chiral ferroelectrics.
Related Concept Videos
Reduction of Alkenes: Asymmetric Catalytic Hydrogenation
The metal catalyst used can be either heterogeneous or homogeneous. When hydrogenation of an alkene generates a chiral center, a pair of enantiomeric products is expected to form. However, an enantiomeric excess of one of the products can be facilitated using an enantioselective reaction or an...
Chirality
Chiral objects exhibit a sense of handedness when they interact with another chiral object. For example, our left foot can only fit in the left shoe and not in the right shoe. Achiral objects — objects that have...
Molecules with Multiple Chiral Centers
Chirality at Nitrogen, Phosphorus, and Sulfur
A consequence of chirality is the need for enantiomeric resolution. While this is theoretically possible for all...
Prochirality

