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Use of MRI-ultrasound Fusion to Achieve Targeted Prostate Biopsy
Published on: April 9, 2019
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Design and evaluation of an MRI-ready, self-propelled needle for prostate interventions
Jette Bloemberg1, Fabian Trauzettel1, Bram Coolen2
1Bio-Inspired Technology Group (BITE), Department of Biomechanical Engineering, Faculty of Mechanical, Maritime and Materials Engineering, Delft University of Technology, Delft, The Netherlands.
Plos One
|September 7, 2022
Summary
This study introduces a bioinspired, self-propelled needle for prostate cancer procedures. The novel needle design minimizes tissue damage during insertion, improving accuracy for MRI-guided treatments.
Area of Science:
- Biomedical Engineering
- Robotics
- Oncology
Background:
- Prostate cancer diagnosis and treatment necessitate precise needle insertion.
- Standard needle insertion can cause tissue deformation, leading to errors and damage.
- Minimizing tissue motion is crucial for accurate MRI-guided interventions.
Purpose of the Study:
- To develop and evaluate a prototype self-propelled needle inspired by wasp locomotion.
- To assess the needle's ability to move with zero external force, reducing tissue displacement.
- To ensure the needle's actuation system is safe for use within Magnetic Resonance Imaging (MRI) environments.
Main Methods:
- A bioinspired needle prototype was designed using 3D printed components and six parallel Nitinol rods.
- Self-propulsion was achieved through a sequential advancing and retracting mechanism of needle segments.
- The prototype was tested in ex vivo human prostate tissue within a preclinical MRI scanner.
Main Results:
- The self-propelled needle was successfully visualized in MR images.
- The needle demonstrated effective self-propulsion through prostate tissue.
- A high slip ratio (0.78-0.95) was achieved, indicating efficient movement relative to the tissue.
Conclusions:
- The wasp-inspired self-propelled needle offers a promising approach to minimize tissue motion during insertion.
- This technology has the potential to enhance the accuracy and safety of MRI-guided prostate cancer treatments, such as focal laser ablation.
- Further development could lead to improved outcomes for minimally invasive prostate cancer therapies.

