Taming PH₃: State of the Art and Future Directions in Synthesis

Appetite for reactions involving PH₃ has grown in the past few years. This in part is due to the ability to generate PH₃ cleanly and safely via digestion of cheap metal phosphides with acids, thus avoiding pressurized cylinders and specialized equipment. In this perspective we highlight current trends in forming new P-C/P-OC bonds with PH₃ and discuss the challenges involved with selectivity and product separation encumbering these reactions. We highlight the reactivity of PH₃ with main group reagents, building on the early pioneering work with transition metal complexes and PH₃. Additionally, we highlight the recent renewal of interest in alkali metal sources of H₂P^- which are proving to be useful synthons for chemistry across the periodic table. Such MPH₂ sources are being used to generate the desired products in a more controlled fashion and are allowing access to unexplored phosphorus-containing species.