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Related Experiment Video

Updated: Aug 29, 2025

Isolation of Adipogenic and Fibro-Inflammatory Stromal Cell Subpopulations from Murine Intra-Abdominal Adipose Depots

Isolation of Adipogenic and Fibro-Inflammatory Stromal Cell Subpopulations from Murine Intra-Abdominal Adipose Depots

Published on: August 16, 2020

Adipose Tissue Remodeling in Pathophysiology.

Christopher Auger¹, Shingo Kajimura^1,2

¹Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA;

Annual Review of Pathology

|September 7, 2022

Summary

This summary is machine-generated.

Adipose tissue is an active endocrine organ influencing systemic health. Understanding its complex roles and dysfunction is key to developing new treatments for metabolic disorders like obesity.

Keywords:

adipose tissue browning burns cachexia fibrosis infectious diseases

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Last Updated: Aug 29, 2025

Isolation of Adipogenic and Fibro-Inflammatory Stromal Cell Subpopulations from Murine Intra-Abdominal Adipose Depots

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Published on: August 16, 2020

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Localization, Identification, and Excision of Murine Adipose Depots

Localization, Identification, and Excision of Murine Adipose Depots

Published on: December 4, 2014

Area of Science:

Endocrinology
Metabolic Biology
Physiology

Background:

Adipose tissue, beyond energy storage, functions as a dynamic endocrine organ.
Dysregulation within adipose tissue contributes to systemic diseases, including obesity and type 2 diabetes.
Current therapeutic strategies rarely target adipose tissue maladaptations.

Purpose of the Study:

To review the distinct adipocyte subtypes, their origins, and secretory functions.
To explore the intricate interplay within adipose tissue and its role in disease.
To highlight the potential for targeting adipose tissue in novel therapeutic development.

Main Methods:

Literature review focusing on adipose tissue biology and disease.
Analysis of adipocyte subtypes, development, and secretory roles.
Examination of the relationship between adipose tissue and various disease states.

Main Results:

Adipose tissue comprises diverse adipocyte subtypes with specific origins and functions.
Adipose tissue actively participates in the initiation and progression of diseases.
Understanding adipose tissue dynamics offers therapeutic targets for metabolic and infectious diseases.

Conclusions:

Adipose tissue is a critical endocrine regulator with significant implications for systemic health.
Targeting adipose tissue dysfunction presents a promising avenue for novel therapeutic interventions.
Further research into adipose biology is essential for advancing treatment strategies for obesity and other diseases.