Bisphenol A, T_H17 cells, and allergy: a commentary

Area of Science:

• Immunology
• Toxicology
• Endocrinology

Background:

• Bisphenol A (BPA) is a chemical with potential endocrine-disrupting properties.
• Recent European Food Safety Authority (EFSA) draft opinion identified immune system effects as most sensitive to BPA.
• T-helper 17 (T_H17) cells in mice spleens were identified as a critical effect marker for inflammation.

Purpose of the Study:

• To summarize the role of T_H17 cells in immune responses.
• To review literature on BPA's influence on T_H17 cells and inflammatory responses.
• To evaluate the appropriateness of a revised Tolerable Daily Intake (TDI) for BPA.

Main Methods:

• Literature review and commentary.
• Analysis of studies on BPA and T_H17 cell frequency.
• Assessment of evidence for BPA-induced lung inflammation and respiratory allergy.

Main Results:

• Uncertainties exist regarding BPA's effects on T_H17 cells and lung inflammation in mice.
• Human studies lack consistent evidence linking BPA exposure to inflammation or allergy.
• Questions remain about the species-specific immune effects of BPA.

Conclusions:

• The proposed significant reduction in BPA's TDI is not currently supported by robust scientific evidence.
• Further research is needed to clarify BPA's impact on the immune system and immune responses.
• Inconsistencies across studies and species necessitate a cautious approach to regulatory decisions.