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Author Spotlight: Developing a Disposable Dosator for Preclinical Testing of Dry Powder Inhalers in Small Animal Models
Published on: August 18, 2023
966
Recent developments in lactose blend formulations for carrier-based dry powder inhalation
Gerald A Hebbink1, Maarten Jaspers1, Harry J W Peters1
1DFE Pharma, Kleverstrasse 187, 47568 Goch, Germany.
Advanced Drug Delivery Reviews
|September 7, 2022
Summary
Lactose remains the top excipient for dry powder inhalation (DPI) formulations. Optimizing lactose properties and processing is key to enhancing inhalable medicine performance.
Area of Science:
- Pharmaceutical Sciences
- Materials Science
Background:
- Lactose is the predominant excipient in carrier-based dry powder inhalation (DPI) formulations.
- While theories exist for carrier roles, each DPI formulation requires a unique development approach.
Purpose of the Study:
- To review recent advancements in lactose-based DPI formulations.
- To highlight the importance of optimizing lactose properties and processing for inhalable medicine.
Main Methods:
- Review of literature on lactose carrier particle properties (size, shape, morphology).
- Analysis of blending and filling processes for DPI formulations.
- Examination of the role of ternary agents in DPI formulations.
Main Results:
- Lactose's versatility allows for optimization of individual DPI formulations.
- Material properties of lactose carriers significantly impact formulation performance.
- Processing techniques like blending and filling are critical for adhesive mixtures.
Conclusions:
- Lactose continues to be the preferred excipient for carrier-based DPI formulations.
- Further developments in lactose-based DPI formulations are essential for improving inhalable drug delivery.
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