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Related Experiment Video

Updated: Aug 29, 2025

Author Spotlight: Non-Surgical Treatment of Melasma– Microneedling with Tranexamic Acid

Author Spotlight: Non-Surgical Treatment of Melasma– Microneedling with Tranexamic Acid

Published on: January 19, 2024

Tranexamic acid for safer surgery: the time is now.

, Michael P W Grocott¹, Mike Murphy²

¹Royal College of Anaesthetists, London, UK; NIHR Southampton Biomedical Research Centre, University Hospital Southampton/University of Southampton, Southampton, UK.

British Journal of Anaesthesia

|September 7, 2022

Summary

Tranexamic acid significantly reduces major surgical bleeding by 25%, with minimal risk of blood clots. Wider use of this antifibrinolytic agent enhances patient safety and reduces healthcare costs.

Keywords:

bleeding clinical trial surgery thromboembolic events tranexamic acid

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Technique and Patient Selection Criteria of Right Anterior Mini-Thoracotomy for Minimal Access Aortic Valve Replacement

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Area of Science:

Anesthesiology
Cardiovascular Medicine
Surgical Innovation

Background:

The POISE-3 trial investigated the efficacy of tranexamic acid in reducing peri-operative bleeding.
Previous research supports tranexamic acid's role in managing surgical hemorrhage.

Discussion:

Tranexamic acid demonstrated a 25% reduction in major bleeding events.
The study found a low probability of increased thromboembolic events with tranexamic acid use.
Implementing tranexamic acid can improve overall surgical safety and patient outcomes.

Key Insights:

Tranexamic acid is a safe and effective agent for reducing surgical bleeding.
Wider adoption of tranexamic acid can prevent unnecessary blood transfusions.
Reduced blood transfusions mitigate risks of transfusion-transmitted infections.

Outlook:

Inclusion of tranexamic acid consideration in safe surgery checklists is recommended.
Evidence supports the expanded use of tranexamic acid in surgical settings.
Adoption of tranexamic acid can lead to significant healthcare savings.