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Risk factors of vestibular migraine-related brain white matter lesions
Yu Shen1,2, Defu Li3, Qian Cao1
1Department of Neurology, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
Objective And Purpose:
Migraine is related to white matter lesions (WMLs), and attack frequency and duration in migraine patients are thought to increase WMLs. However, the relationship between vestibular migraine (VM) and WMLs remains unclear. This study explored the risk factors for WMLs in VM patients and provided a basis for the prevention of WMLs in VM patients.
Methods:
A large single-center cross-sectional study of patients with VM was conducted. None of the patients had comorbidities, such as hypertension and diabetes, or adverse lifestyle habits (smoking and drinking). All patients were divided into WML + and WML- groups after assessment of WMLs using magnetic resonance imaging (MRI). After collecting the patient's detailed medical history, statistical analysis was performed.
Results:
In univariate analysis, the frequency of vertigo was statistically significant between the WML + and WML- groups. However, there was no significant difference in other clinical features. Multivariate regression analysis found that the frequency of vertigo (OR 2.399; 95% CI 1.014-5.679; p = 0.046) was an independent risk factor for WMLs. High frequency of vertigo episodes showed more pronounced risk factors (OR 9.607; 95% CI 1.061-87.014; p = 0.044).
Conclusion:
These results substantiate that vertigo frequency is an independent risk factor for WMLs in VM. A high frequency of vertigo episodes is more likely to be associated with WMLs than a low frequency. These results suggest a possible approach to the prevention of WMLs in VM patients.
Insights
Vertigo frequency is an independent risk factor for white matter lesions (WMLs) in vestibular migraine (VM) patients. High-frequency vertigo episodes increase the likelihood of developing WMLs, suggesting a preventative approach.
Area of Science:
- Neurology
- Neuroimaging
- Ophthalmology
Background:
- Migraine is associated with white matter lesions (WMLs).
- The link between vestibular migraine (VM) and WMLs is not well understood.
- Understanding VM's impact on WMLs is crucial for patient prevention strategies.
Purpose of the Study:
- To investigate risk factors for WMLs in VM patients.
- To establish a basis for preventing WMLs in individuals with VM.
- To clarify the relationship between VM and WMLs.
Main Methods:
- A cross-sectional study involving VM patients without comorbidities or adverse lifestyle habits.
- Patients were categorized into WML-positive and WML-negative groups via MRI.
- Detailed medical histories were collected and statistically analyzed.
Main Results:
- Vertigo frequency was a significant factor differentiating WML groups.
- Multivariate analysis identified vertigo frequency as an independent risk factor for WMLs (OR 2.399).
- A high frequency of vertigo episodes showed a more pronounced risk (OR 9.607).
Conclusions:
- Vertigo frequency is confirmed as an independent risk factor for WMLs in VM.
- Increased vertigo episode frequency correlates with a higher likelihood of WMLs.
- Findings suggest potential preventative measures for WMLs in VM patients.
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