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Camels' biological fluids contained nanobodies: promising avenue in cancer therapy
Nouf S Al-Numair1,2, Abdulrahman Theyab3,4, Faisal Alzahrani5,6
1Center of Genomic Medicine, King Faisal Specialist Hospital & Research Center, Riyadh, Saudi Arabia.
Abstract:
Cancer is a major health concern and accounts for one of the main causes of death worldwide. Innovative strategies are needed to aid in the diagnosis and treatment of different types of cancers. Recently, there has been an evolving interest in utilizing nanobodies of camel origin as therapeutic tools against cancer. Nanotechnology uses nanobodies an emerging attractive field that provides promises to researchers in advancing different scientific sectors including medicine and oncology. Nanobodies are characteristically small-sized biologics featured with the ability for deep tissue penetration and dissemination and harbour high stability at high pH and temperatures. The current review highlights the potential use of nanobodies that are naturally secreted in camels' biological fluids, both milk and urine, in the development of nanotechnology-based therapy for treating different typesQuery of cancers and other diseases. Moreover, the role of nano proteomics in the invention of novel therapeutic agents specifically used for cancer intervention is also illustrated.
Insights
Camel-derived nanobodies offer a novel nanotechnology approach for cancer therapy. These small, stable biologics show potential for deep tissue penetration, aiding in cancer diagnosis and treatment.
Area of Science:
- Oncology
- Nanotechnology
- Biotechnology
Background:
- Cancer remains a leading global cause of mortality, necessitating innovative diagnostic and therapeutic strategies.
- Camel-derived nanobodies are emerging as promising tools in oncology due to their unique properties.
Purpose of the Study:
- To review the potential of camel-derived nanobodies in nanotechnology-based cancer therapy.
- To explore the role of nanoproteomics in developing novel cancer therapeutic agents.
Main Methods:
- Review of current literature on camel-derived nanobodies and their applications in cancer.
- Discussion of nanobody characteristics, including size, tissue penetration, and stability.
- Exploration of nanoproteomics for therapeutic agent discovery.
Main Results:
- Nanobodies are small, stable biologics facilitating deep tissue penetration.
- Camel milk and urine are sources of nanobodies with therapeutic potential.
- Nanoproteomics can aid in identifying novel cancer intervention agents.
Conclusions:
- Camel-derived nanobodies represent a viable nanotechnology for developing novel cancer treatments.
- Further research into nanobody applications and nanoproteomics can advance cancer therapy.
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