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The emerging multifaceted role of PINK1 in cancer biology

Meng Wang1,2,3,4, Shijia Luan2, Xiang Fan2

  • 1Department of Colorectal Surgery, Cancer Hospital of University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Hangzhou, China.

Cancer Science
|September 8, 2022
PubMed

Insights

Phosphatase and tensin homolog-induced kinase 1 (PINK1) has a dual role in cancer, acting as both a tumor promoter and suppressor. This review explores PINK1's functions in cancer biology, including its role in mitophagy.

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Oncology

Background:

  • Phosphatase and tensin homolog-induced kinase 1 (PINK1) is crucial for cellular functions and implicated in early-onset Parkinson's disease.
  • Emerging evidence suggests PINK1 regulates key cancer cell processes like cytoplasmic homeostasis, survival, and death.
  • PINK1 exhibits context-dependent dual roles as a tumor promoter or suppressor.

Purpose of the Study:

  • To review the mechanistic roles of PINK1 in cancer biology.
  • To explore PINK1's interplay with cellular context and its functions beyond mitophagy.
  • To provide insights into PINK1's involvement in physiological and pathophysiological processes in cancer.

Main Methods:

  • Literature review of peer-reviewed articles.
  • Data mining of The Cancer Genome Atlas (TCGA).
  • Analysis of cell-based assays.

Main Results:

  • PINK1's dual role as a tumor promoter or suppressor is context-dependent.
  • PINK1 is increasingly recognized for its involvement in mitophagy.
  • PINK1 exhibits non-mitophagy related functions involving other organelles.

Conclusions:

  • Understanding PINK1's multifaceted roles is essential for cancer biology.
  • PINK1's dual functions highlight its complex involvement in tumorigenesis.
  • Further research into PINK1's mechanisms can inform cancer therapeutic strategies.
Keywords:
PINK1antitumorcancermitophagyoncogene

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