Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drugs for Treatment of Diarrhea-Predominant IBS01:17

Drugs for Treatment of Diarrhea-Predominant IBS

275
Diarrhea-predominant irritable bowel syndrome (IBS-D) is a subtype of IBS characterized primarily by frequent, loose, or watery stools, abdominal pain, and abdominal discomfort. Therapeutic approaches to managing IBS-D include dietary changes, stress management techniques, and pharmaceutical interventions.
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
275
Management of Insomnia01:19

Management of Insomnia

313
The sleep cycle, an integral part of human health, consists of several stages with distinct characteristics and functions. It begins with a transition from wakefulness to sleep, known as the light sleep phase, followed by the restorative deep sleep phase, essential for physical recovery and growth. The cycle concludes with the Rapid Eye Movement (REM) phase, characterized by high brain activity and vivid dreaming. Insomnia, a prevalent sleep disorder, involves difficulty falling asleep, staying...
313
Irritable Bowel Syndrome III: Medical and Nursing Management01:30

Irritable Bowel Syndrome III: Medical and Nursing Management

277
Managing Irritable Bowel Syndrome (IBS) involves a multifaceted approach, including lifestyle modifications, dietary changes, and medication.
277
Drugs for Treatment of Constipation-Predominant IBS01:21

Drugs for Treatment of Constipation-Predominant IBS

301
Pharmacological therapies for IBS-C are designed to alleviate abdominal discomfort and enhance bowel function. In patients with IBS-C, fiber supplements may help soften stools and decrease straining, but may also lead to increased gas production and bloating. Osmotic laxatives like milk of magnesia are frequently used to soften stools and increase stool frequency in IBS-C patients. In addition, two drugs approved for use in severe IBS-C adult cases are linaclotide (Linzess) and lubiprostone...
301
Irritable Bowel Syndrome I: Introduction01:17

Irritable Bowel Syndrome I: Introduction

353
Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
353
Sedatives and Hypnotics Drugs: Miscellaneous Agents01:17

Sedatives and Hypnotics Drugs: Miscellaneous Agents

231
Sedatives and hypnotics encompass a wide range of substances, each with its unique mechanism of action, uses, and potential adverse effects.
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...
231

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A cross-sectional survey about behavior of wearing condoms among college students who engage in sexual activity: the mediating role of attitudes of preventive behavior.

Frontiers in public health·2025
Same author

Lymphatic Malformation: Classification, Pathogenesis, and Therapeutic Strategies.

Annals of vascular surgery·2025
Same author

Cardiac magnetic resonance feature tracking evaluates left atrial strain in patients with systemic lupus erythematosus and mitral regurgitation.

Lupus·2025
Same author

A Spatial analysis of chickenpox in Chongqing, China, during 2015-2023.

Scientific reports·2025
Same author

A 14-year influenza reinfection surveillance in Chongqing, China: A retrospective analysis.

Human vaccines & immunotherapeutics·2025
Same author

Urban pertussis epidemiological patterns in a highly vaccinated megacity: Policy impacts and control strategies in Chongqing, China, 2005-2024.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases·2025
Same journal

HER2-mutated lung squamous cell carcinoma responding to trastuzumab deruxtecan followed by pyrotinib: a Case Report.

Frontiers in pharmacology·2026
Same journal

Awareness, attitudes, and self-reported clinical management of antimicrobial-associated neurocognitive adverse effects among healthcare providers in Saudi Arabia.

Frontiers in pharmacology·2026
Same journal

Low-dose dasatinib in second-line therapy or beyond for the treatment of chronic-phase chronic myeloid leukemia: a real-world cohort study.

Frontiers in pharmacology·2026
Same journal

Natural products reshape osteosarcoma cell fate: promoting cell death.

Frontiers in pharmacology·2026
Same journal

<i>Leonurus japonicus</i> Houtt. extract containing isoquercitrin reduces airway inflammation in mice with allergic asthma.

Frontiers in pharmacology·2026
Same journal

Enhancing diabetes treatment by targeted nucleic acid and drug delivery using cell-penetrating peptides, peptide nucleic acids, and receptor targeting.

Frontiers in pharmacology·2026
See all related articles

Related Experiment Video

Updated: Aug 29, 2025

Meta-Analysis of the Effectiveness and Safety of Shugan Jieyu Capsules for the Treatment of Insomnia
04:34

Meta-Analysis of the Effectiveness and Safety of Shugan Jieyu Capsules for the Treatment of Insomnia

Published on: February 17, 2023

1.2K

Alleviating insomnia should decrease the risk of irritable bowel syndrome: Evidence from Mendelian randomization.

Wenzhao Bao1, Li Qi2, Yin Bao1

  • 1Department of Anesthesiology, The Affiliated Hospital of Inner Mongolia University for the Nationalities, Tongliao, China.

Frontiers in Pharmacology
|September 8, 2022
PubMed
Summary
This summary is machine-generated.

Genetic susceptibility to insomnia increases irritable bowel syndrome (IBS) risk. Improving sleep quality, particularly addressing insomnia, may help prevent IBS, establishing a causal link.

Keywords:
Mendelian randomizationcausal inferenceinsomniairritable bowel syndromesleep disorder

More Related Videos

Perturbations of Circulating miRNAs in Irritable Bowel Syndrome Detected Using a Multiplexed High-throughput Gene Expression Platform
10:37

Perturbations of Circulating miRNAs in Irritable Bowel Syndrome Detected Using a Multiplexed High-throughput Gene Expression Platform

Published on: November 30, 2016

8.4K
Heat-sensitive Moxibustion as a Traditional Chinese Medicine Therapy for Chronic Obstructive Pulmonary Disease Combined with Insomnia
04:59

Heat-sensitive Moxibustion as a Traditional Chinese Medicine Therapy for Chronic Obstructive Pulmonary Disease Combined with Insomnia

Published on: May 30, 2025

465

Related Experiment Videos

Last Updated: Aug 29, 2025

Meta-Analysis of the Effectiveness and Safety of Shugan Jieyu Capsules for the Treatment of Insomnia
04:34

Meta-Analysis of the Effectiveness and Safety of Shugan Jieyu Capsules for the Treatment of Insomnia

Published on: February 17, 2023

1.2K
Perturbations of Circulating miRNAs in Irritable Bowel Syndrome Detected Using a Multiplexed High-throughput Gene Expression Platform
10:37

Perturbations of Circulating miRNAs in Irritable Bowel Syndrome Detected Using a Multiplexed High-throughput Gene Expression Platform

Published on: November 30, 2016

8.4K
Heat-sensitive Moxibustion as a Traditional Chinese Medicine Therapy for Chronic Obstructive Pulmonary Disease Combined with Insomnia
04:59

Heat-sensitive Moxibustion as a Traditional Chinese Medicine Therapy for Chronic Obstructive Pulmonary Disease Combined with Insomnia

Published on: May 30, 2025

465

Area of Science:

  • Genetics
  • Gastroenterology
  • Sleep Medicine

Background:

  • Associations between sleep disturbances and irritable bowel syndrome (IBS) are documented.
  • A causal relationship between sleep and IBS remains to be established.

Purpose of the Study:

  • To investigate the potential causal relationship between genetically determined sleep traits and IBS using Mendelian randomization.
  • To identify specific sleep factors that may causally influence IBS risk.

Main Methods:

  • Employed Mendelian randomization (MR) design utilizing genome-wide association study (GWAS) data for sleep traits and IBS.
  • Used inverse-variance weighted (IVW) method for causal effect estimation, with meta-analysis for combining estimates.
  • Performed multivariable MR and reverse MR analyses to assess independence and directionality of effects.

Main Results:

  • Genetic liability to insomnia was associated with an increased risk of IBS (meta-analysis OR = 2.70).
  • Short sleep duration also showed a genetic association with increased IBS risk (meta-analysis OR = 2.46).
  • Insomnia was identified as an independent risk factor for IBS, even after adjusting for chronotype and sleep duration.

Conclusions:

  • Genetic predisposition to insomnia causally increases the risk of developing IBS.
  • Targeting insomnia and improving overall sleep quality represent potential strategies for IBS prevention.