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Impact of a probiotic chewable tablet on stool habits and microbial profile in children with functional constipation:

Dan Gan1, Jialun Chen1, Xin Tang1

  • 1Sirio Pharma Co., Ltd., Shantou, China.

Frontiers in Microbiology
|September 8, 2022
PubMed

Insights

A probiotic chewable tablet containing Lactobacillus acidophilus DDS-1® and Bifidobacterium animalis subsp. lactis UABla-12™ improved stool frequency and consistency in children with functional constipation (FC). This study highlights the potential of probiotics for managing childhood constipation.

Area of Science:

  • Pediatrics
  • Gastroenterology
  • Microbiology

Background:

  • Childhood functional constipation (FC) is a common, multifactorial condition.
  • Clinical management of FC in children presents significant challenges.
  • Rome III criteria define functional constipation in pediatric populations.

Purpose of the Study:

  • To evaluate the efficacy of a specific probiotic formulation in managing childhood functional constipation.
  • To assess the impact of the probiotic on stool frequency and consistency.
  • To compare the effects of the probiotic chewable tablet against a placebo.

Main Methods:

  • A randomized, single-blind, placebo-controlled, multi-center trial.
  • Involved 92 children aged 4-12 diagnosed with FC.
  • Participants received either a probiotic (Lactobacillus acidophilus DDS-1® and Bifidobacterium animalis subsp. lactis UABla-12™) or placebo twice daily for 4 weeks.

Main Results:

  • The probiotic group exhibited a faster and more significant normalization of stool frequency compared to the placebo group.
  • A notable decrease in hard stools (from 43% to 14%) was observed in the probiotic group.
  • An increase in normal defecation (from 56% to 80%) was recorded in children receiving the probiotic.

Conclusions:

  • The probiotic chewable tablet containing L. acidophilus DDS-1® and B. Lactis UABla-12™ demonstrated efficacy in treating childhood functional constipation.
  • This probiotic formulation shows potential as a daily therapeutic option for pediatric FC.
  • The study supports the use of targeted probiotics for normalizing bowel habits in children.

Keywords:
childrenclinical trialfunctional constipationmicrobiomeprobiotic chewable

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