Adenoid Ameloblastoma with Dentinoid: A systematic review

Area of Science:

• Oral Pathology
• Odontogenic Neoplasms
• Surgical Pathology

Background:

• Ameloblastoma and adenomatoid odontogenic tumors are common odontogenic neoplasms.
• Adenoid ameloblastoma with dentinoid (AAD) is an extremely rare hybrid variant, sharing features of both.
• AAD represents a rare but potentially aggressive benign odontogenic neoplasm.

Purpose of the Study:

• To compile and present demographic, clinical, radiographic, and histopathological features of AAD.
• To review treatment and outcomes for all reported AAD cases in the literature.
• To highlight the diagnostic challenges and clinical significance of AAD.

Main Methods:

• Systematic literature review of all reported cases of AAD.
• Analysis of demographic, clinical, radiographic, and histopathological data.
• Compilation of treatment modalities and patient outcomes.

Main Results:

• AAD exhibits a unique combination of ameloblastoma and adenomatoid odontogenic tumor characteristics.
• The lesion shows a tendency for underdiagnosis, necessitating meticulous histopathological evaluation.
• Recent case reports suggest an increasing recognition of AAD.

Conclusions:

• AAD is a rare entity requiring careful histopathological examination for accurate diagnosis.
• Underdiagnosis is a significant concern, potentially leading to delayed or inadequate treatment.
• AAD's distinct features may warrant its classification as a separate entity in future WHO classifications.