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Ceramic Omnidirectional Bioprinting in Cell-Laden Suspensions for the Generation of Bone Analogs
Published on: August 8, 2022
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Bioinspired laminated bioceramics with high toughness for bone tissue engineering
Jinzhou Huang1,2, Dong Zhai1, Jianmin Xue1
1State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, P.R. China.
Regenerative Biomaterials
|September 8, 2022
Summary
Researchers developed tough, strong laminated bioceramics for bone tissue engineering. These materials mimic natural structures, offering improved mechanical properties and bone healing potential.
Area of Science:
- Biomaterials Science
- Tissue Engineering
- Materials Science
Background:
- Fabricating brittle bioceramics for bone tissue engineering remains a challenge.
- Natural materials with hierarchical structures inspire toughness.
- Calcium silicate-based bioceramics often lack sufficient mechanical strength and toughness.
Purpose of the Study:
- To develop laminated MXene/calcium silicate-based (L-M/CS) bioceramics with enhanced mechanical and biological properties.
- To overcome the brittleness of traditional bioceramics.
- To provide a bionic strategy for bone tissue engineering biomaterials.
Main Methods:
- Directional assembly-sintering approach.
- Fabrication of laminated MXene/calcium silicate-based bioceramics.
- Characterization of mechanical properties, degradability, and biocompatibility.
Main Results:
- L-M/CS bioceramics exhibited significantly enhanced toughness (2.23 MPa·m1/2) and high flexural strength (145 MPa), comparable to cortical bone.
- The bioceramics showed suitable degradability and good biocompatibility.
- Osteogenesis-related gene expression was stimulated, linked to the Wnt signaling pathway.
Conclusions:
- The developed L-M/CS bioceramics offer excellent mechanical and biological properties for bone tissue engineering.
- The directional assembly-sintering approach provides a viable strategy for creating tough, bionic bioceramics.
- These findings advance the development of advanced biomaterials for skeletal repair and regeneration.
