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Two-photon polymerization for 3D biomedical scaffolds: Overview and updates.
Xian Jing1, Hongxun Fu1, Baojun Yu1
1Key Laboratory of Micro/Nano and Ultra-precision Manufacturing, School of Mechatronic Engineering, Changchun University of Technology, Changchun, Jilin, China.
Frontiers in Bioengineering and Biotechnology
|September 8, 2022
Summary
Two-photon polymerization (TPP) enables advanced 3D microfabrication of complex biomedical scaffolds. This review explores TPP
Area of Science:
- Biomedical Engineering
- Materials Science
- Additive Manufacturing
Background:
- Novel 3D microfabrication techniques are crucial for high-resolution, complex structures.
- Two-photon polymerization (TPP) offers unique advantages for additive manufacturing.
Purpose of the Study:
- To review the development and applications of TPP in fabricating complex 3D biomedical scaffolds.
- To discuss the multidisciplinary perspectives of TPP in this field.
Main Methods:
- Overview of TPP principles, including two-photon absorption (TPA).
- Discussion of material requirements and chemical approaches for TPP.
- Analysis of manufacturing strategies and engineering aspects.
Main Results:
- TPP allows for arbitrary geometry fabrication with sub-diffraction limit resolution.
- Fabricated scaffolds mimic natural extracellular matrix, aiding cell behavior studies.
- TPP meets requirements for cytobiology, tissue engineering, and regenerative medicine.
Conclusions:
- TPP is a powerful technique for advanced 3D biomedical scaffold fabrication.
- The review highlights current limitations and future prospects of TPP in this domain.
