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FOXM1 is regulated by DEPDC1 to facilitate development and metastasis of oral squamous cell carcinoma

Jing Qiu1, Yongping Tang1, Lan Liu1

  • 1Department of Stomatology, Qingdao Municipal Hospital, Qingdao, Shandong, China.

Frontiers in Oncology
|September 8, 2022
PubMed

Insights

Disheveled, EGL-10, Pleckstrin domain containing 1 (DEPDC1) promotes oral squamous cell carcinoma (OSCC) growth by interacting with FOXM1 and activating Wnt/β-catenin signaling. Targeting this DEPDC1/FOXM1/β-catenin complex offers a potential therapeutic strategy for OSCC.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • The role of the DEPDC1 oncogene in oral squamous cell carcinoma (OSCC) remains largely undetermined.
  • Understanding DEPDC1's function is crucial for developing targeted therapies for OSCC.

Purpose of the Study:

  • To investigate the impact of DEPDC1 expression on OSCC growth and development.
  • To elucidate the molecular mechanisms underlying DEPDC1's function in OSCC pathogenesis.

Main Methods:

  • Utilized animal models, cell lines, and human OSCC tissue samples.
  • Performed co-immunoprecipitation and immunofluorescence assays to study protein interactions.
  • Analyzed DEPDC1's effect on Wnt/β-catenin signaling pathway activation.

Main Results:

  • DEPDC1 expression was found to be elevated in OSCC cell lines and human tissues.
  • Restored DEPDC1 expression promoted OSCC tumor development both in vivo and in vitro.
  • DEPDC1 was identified to interact with FOXM1 and facilitate Wnt/β-catenin signaling, leading to increased nuclear β-catenin.

Conclusions:

  • DEPDC1, in conjunction with FOXM1, drives OSCC pathogenesis through the Wnt/β-catenin signaling pathway.
  • The novel DEPDC1/FOXM1/β-catenin complex represents a promising therapeutic target for oral squamous cell carcinoma.
Keywords:
DEP domain containing 1FoxM1migrationoral squamous cell carcinomaproliferation

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