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Hypertension as a risk factor for atherosclerosis: Cardiovascular risk assessment

Anastasia V Poznyak1, Nikolay K Sadykhov2, Andrey G Kartuesov3

  • 1Institute for Atherosclerosis Research, Moscow, Russia.

Frontiers in Cardiovascular Medicine
|September 8, 2022
PubMed

Insights

Hypertension, or high blood pressure, is a major modifiable risk factor for atherosclerosis, a precursor to cardiovascular diseases. This review summarizes current data on hypertension

Area of Science:

  • Cardiovascular Science
  • Pathophysiology
  • Public Health

Background:

  • Atherosclerosis is a primary precursor to cardiovascular diseases (CVD), contributing significantly to morbidity and mortality.
  • While atherosclerosis pathogenesis is known, its precise trigger mechanism remains an area requiring further elucidation.
  • Numerous risk factors exist, including permanent (age, genetics) and modifiable factors like tobacco use, inactivity, poor diet, obesity, type 2 diabetes (T2D), dyslipidemia, and hypertension.

Purpose of the Study:

  • To review and synthesize current data on hypertension as a critical risk factor for atherosclerosis development.
  • To examine the role of hypertension in atherogenesis and discuss associated risk assessment strategies.

Main Methods:

  • Literature review focusing on studies investigating hypertension and atherosclerosis.
  • Synthesis of data regarding hypertension's impact on atherogenesis and risk stratification.

Main Results:

  • Hypertension is identified as the most prevalent modifiable risk factor for atherosclerosis.
  • High blood pressure is extensively studied and recognized as a key contributor to the development of atherosclerosis.
  • The review consolidates information on hypertension's role in atherosclerosis and its implications for risk assessment.

Conclusions:

  • Hypertension significantly contributes to atherosclerosis development and is a primary target for CVD prevention.
  • Understanding hypertension's role is crucial for accurate atherosclerosis risk assessment and management.
  • Further research into the precise mechanisms linking hypertension to atherogenesis is warranted.

Keywords:
atherosclerosiscardiovascular diseasecardiovascular riskhypertensionvessels

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