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Updated: Aug 29, 2025

Author Spotlight: Advancing Syphilis Research — Innovations in Treponema pallidum Cultivation and Genetic Engineering
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Prioritizing syphilis control: Now is the time for action.

Joseph D Tucker1,2,3, Gifty Marley1,3, Michael Marks2,4

  • 1Institute for Global Health and Infectious Diseases, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.

Frontiers in Medicine
|September 8, 2022
PubMed
Summary

Syphilis control needs urgent prioritization. Lessons from COVID-19, including improved diagnostics and public engagement, offer new opportunities to address this neglected sexually transmitted infection (STI).

Keywords:
COVID-19advocacycrowdsourcingpartner servicessyphilis

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Area of Science:

  • Public Health
  • Infectious Diseases
  • Epidemiology

Background:

  • Syphilis control received less attention and fewer resources than HIV and other STIs pre-pandemic.
  • Neglect stemmed from diagnostic challenges, historical racism in research, limited partner services, and poor public engagement.

Purpose of the Study:

  • To highlight the urgent need to prioritize syphilis control programs and research.
  • To leverage advances and lessons learned during the COVID-19 pandemic for syphilis control.

Main Methods:

  • Review of pre-pandemic and pandemic-era STI control strategies.
  • Analysis of how COVID-19 impacted syphilis diagnostics, health equity, partner services, and public engagement.

Main Results:

  • COVID-19 accelerated novel syphilis diagnostic pathways like self-testing.
  • The pandemic underscored health inequities driving syphilis transmission and highlighted the need to address historical racism in research.
  • COVID-19 partner tracing efforts potentially enhanced resources for syphilis partner services.
  • The pandemic emphasized the critical role of public engagement in disease control.

Conclusions:

  • Urgent action is required to prioritize syphilis control across diverse settings.
  • Harnessing pandemic-driven innovations can revitalize syphilis prevention and control efforts.
  • Addressing systemic issues like health inequities and historical racism is crucial for effective syphilis control.