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Chronic Pancreatitis II: Collaborative Care01:29

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The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
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The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
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Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
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Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
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[Cell therapy for destructive pancreatitis].

S Yu Gasanova1

  • 1Aliyev Azerbaijan State Institute for Advanced Training of Physicians, Azerbaijan, Baku.

Khirurgiia
|September 8, 2022
PubMed
Summary
This summary is machine-generated.

Mesenchymal stem cell therapy shows promise for severe acute pancreatitis, effectively managing homeostasis disorders and improving microcirculation, especially in patients with the eNOS T774T gene mutation.

Keywords:
MSCseNOS (T774T)endogenous intoxicationimmunitymicrocirculationpancreatitis

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Area of Science:

  • Gastroenterology
  • Regenerative Medicine
  • Medical Genetics

Background:

  • Severe acute pancreatitis presents with significant homeostatic, immune, and microcirculatory dysfunctions.
  • Endothelial NO synthase (eNOS) gene polymorphism, specifically the T774T genotype, is associated with more severe disease manifestations.

Purpose of the Study:

  • To evaluate the therapeutic efficacy of mesenchymal stem cells (MSCs) in patients with severe acute pancreatitis.
  • To assess the impact of MSCs on endogenous intoxication, immune status, and regional microcirculation.

Main Methods:

  • A randomized study of 60 patients with severe acute pancreatitis.
  • Two groups: endoscopic surgical treatment (n=30) and complex therapy with MSCs (n=30).
  • Assessment of homeostasis, immune response, microcirculation, and eNOS gene polymorphism (C774T).

Main Results:

  • MSC therapy in the early phase of severe acute pancreatitis improved homeostasis, inhibited toxemia, restored immune response, and enhanced microcirculation.
  • A particularly positive therapeutic effect was observed in patients with the eNOS T774T gene mutation.
  • The T774T genotype of the eNOS gene was more prevalent in patients with severe acute pancreatitis and pronounced homeostatic disorders.

Conclusions:

  • Mesenchymal stem cell drugs are advisable for early-stage acute pancreatitis, particularly in severe cases.
  • MSC therapy offers a targeted approach to correcting homeostatic abnormalities in severe acute pancreatitis.