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The levels of plasma plasmalogen in retired female rats decrease by ovariectomy and intake of cholesterol-diet
Kiwa Hashiguchi1, Takuma Kikuchi1, Takuya Mizokami2
1Department of Animal Science, Faculty of Agriculture, Iwate University, Morioka, Iwate, Japan.
Bioscience, Biotechnology, and Biochemistry
|September 8, 2022
Summary
This study introduces a new rat model for low plasma plasmalogen levels, mimicking human atherosclerosis. Ovariectomized retired rats showed reduced plasmalogens and increased cholesterol, especially on a high-cholesterol diet.
Area of Science:
- Biochemistry
- Lipid Metabolism
- Aging Research
Background:
- Plasmalogens are vital phospholipids implicated in human health and disease.
- Previous research linked lower plasma choline plasmalogen to atherosclerosis risk factors and aging.
Purpose of the Study:
- To develop an animal model for studying low plasma plasmalogen levels.
- To investigate the impact of aging on plasmalogen metabolism and plasma lipids in ovariectomized rats.
Main Methods:
- Creation of an ovariectomized rat model (Retire + OVX).
- Analysis of plasma plasmalogen and cholesterol levels.
- Assessment of lipid profiles under standard and high-cholesterol diets.
Main Results:
- Ovariectomized retired rats exhibited decreased plasmalogen ratios and elevated plasma cholesterol.
- These changes were exacerbated by a high-cholesterol diet.
- The observed lipid alterations resemble those seen in human atherosclerosis.
Conclusions:
- The ovariectomy model in retired rats effectively replicates low plasma plasmalogen conditions.
- This model serves as a valuable tool for studying plasmalogen-related diseases like atherosclerosis.
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