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Promethazine hydrochloride reduces children's agitation during ocular examination for trauma

Zahra Ghiasi1, Mohammad Hosein Validad2, Shokoufeh Mogharabi Ostadkelayeh3

  • 1Department of Psychiatry and Clinical Psychology, School of Medicine, Zahedan University of Medical Sciences, Zahedan. linooshghiasi@gmail.com.

European Journal of Translational Myology
|September 8, 2022
PubMed

Insights

Promethazine hydrochloride effectively reduced agitation in children undergoing ocular trauma examinations. This medication significantly lowered physical and verbal aggressive behaviors, and hiding behaviors during examinations.

Area of Science:

  • Ophthalmology
  • Pediatric Medicine
  • Clinical Pharmacology

Background:

  • Pediatric ocular examinations for trauma can induce significant agitation, anxiety, and fear.
  • Effective management of agitation is crucial for successful examination and patient care.

Purpose of the Study:

  • To evaluate the efficacy of promethazine hydrochloride in mitigating agitation in pediatric patients during ocular trauma examinations.
  • To compare the effects of promethazine hydrochloride versus placebo on children's behavior during these examinations.

Main Methods:

  • An interventional clinical trial involving 62 pediatric patients with ocular trauma.
  • Patients were divided into two matched groups: case (promethazine hydrochloride) and control (placebo).
  • Promethazine hydrochloride (0.5 mg/kg) or placebo was administered 20 minutes prior to examination, with behavior assessed using a modified Cohen-Mansfield Agitation Inventory (CMAI).

Main Results:

  • Promethazine hydrochloride significantly reduced physical/aggressive behaviors (p < 0.001).
  • Significant reductions were observed in physical/nonaggressive behaviors (p = 0.013), verbal/aggressive behaviors (p < 0.001), and hiding behaviors (p < 0.001) in the promethazine group.
  • The intervention facilitated examinations for children with traumatic ocular injuries.

Conclusions:

  • Promethazine hydrochloride is effective in reducing agitation in children during ocular trauma examinations.
  • The medication aids in managing challenging behaviors, improving the examination process.
  • Further research via randomized controlled trials is recommended to confirm these findings.

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