Related Experiment Video
Updated: Aug 29, 2025

Non-Invasive Electrical Brain Stimulation Montages for Modulation of Human Motor Function
Published on: February 4, 2016
Advances in Non-Invasive Neuromodulation
Brian Brenner1, Tyler Ericson1, Lynn Kohan2,3
1Department of Anesthesiology, Division of Pain Medicine, University of Virginia, Charlottesville, VA, USA.
Purpose Of Review:
Pain medicine is rapidly expanding. The gap in treatment for patients with chronic pain in between traditional conservative therapy and major invasive surgery is closing. Neuromodulation is one therapeutic area that has continued to show promise for treatment of chronic pain. Our aim is to review updates in non-invasive neuromodulation (NIN) techniques as an adjunct for various chronic pain conditions.
Recent Findings:
Overall, the literature suggests that NIN techniques such as tCDS, TMS, TENS, tVNS, and HIFUS/LIFUS have utility in treating various types of chronic pain and have a promising future. There is a better understanding of the mechanistic basis for pain relief from NIN, as well as refinement in technology improving NIN therapy success. Future studies will need to focus on continuing to refine protocols for optimal benefit from NIN as well as implementing larger RCTs to improve the quality of data being generated in the field.

