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Updated: Aug 29, 2025

Tumor Allotransplantation in Drosophila melanogaster with a Programmable Auto-Nanoliter Injector
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NIMA-related kinase-6 (NEK6) as an executable target in cancer

Nagesh Kishan Panchal1, Shruti Mohanty1, Sabina Evan Prince2

  • 1Department of Biomedical Sciences, School of Biosciences and Technology, Vellore Institute of Technology, Vellore, 632014, India.

Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
|September 8, 2022
PubMed

Insights

NEK6, a cell cycle protein, is crucial for mitosis and DNA repair. This review details NEK6

Area of Science:

  • Cell Biology
  • Molecular Oncology

Background:

  • Cancer is characterized by uncontrolled cell division and spread, influenced by cell cycle proteins.
  • NEK6 (NIMA-related kinase 6) is a serine/threonine kinase implicated in cell cycle regulation and human malignancies.

Purpose of the Study:

  • To review the structural and functional roles of NEK6 in cellular processes.
  • To elucidate the association between NEK6 and various cancers.
  • To highlight potential NEK6 inhibitors for cancer therapy.

Main Methods:

  • Literature review of studies on NEK6 function and cancer.
  • Analysis of NEK6's role in mitosis, DNA repair, and apoptosis.
  • Compilation of evidence linking NEK6 expression to different cancer types.

Main Results:

  • NEK6 is vital for mitosis, including spindle formation and chromosome segregation.
  • NEK6 influences DNA repair and can induce apoptosis upon inhibition.
  • Elevated NEK6 expression is observed in multiple cancers, including breast, lung, and liver cancer.

Conclusions:

  • NEK6 is a significant regulator of cell division and a potential oncogene.
  • Targeting NEK6 offers a promising therapeutic strategy for various cancers.
  • Further research into NEK6 inhibitors is warranted for cancer treatment.
Keywords:
ApoptosisCell cycleDNA repairHepatocellular carcinomaNIMA kinases

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