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A New Technique for Quantitative Analysis of Hair Loss in Mice Using Grayscale Analysis
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Systemic Medications Associated With Hair Texture Changes.

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    Medication can alter hair texture, often causing new curling patterns. While some changes reverse after stopping treatment, others may be permanent, necessitating physician awareness.

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    Area of Science:

    • Dermatology
    • Pharmacology
    • Clinical Medicine

    Background:

    • Medication-induced hair texture changes are underreported and poorly understood.
    • These alterations can be a significant concern for patients, alongside hair loss.

    Purpose of the Study:

    • To systematically review and characterize hair texture changes associated with medications.
    • To consolidate existing literature on this under-recognized side effect.

    Main Methods:

    • A comprehensive literature search was conducted in PubMed and Cochrane databases.
    • 31 articles published between 1985 and 2021 were analyzed, including case studies, cohort studies, and one randomized controlled trial.
    • Data from 2594 patients experiencing medication-associated hair changes were compiled.

    Main Results:

    • Antineoplastic agents, antiepileptics, retinoids, immunomodulators, and antiretroviral therapy were the primary drug classes linked to texture changes.
    • The most common change reported was new or exaggerated hair curling.
    • While reversibility was noted across most drug classes, irreversible changes were associated with antiretrovirals, retinoids, and antineoplastics.

    Conclusions:

    • Hair texture alterations are a potential adverse effect of several medication classes.
    • The available literature has limitations in defining incidence rates, ethnicity, and severity.
    • Increased physician awareness is crucial due to the potential psychosocial impact of these changes.