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Updated: Aug 29, 2025

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
Published on: April 22, 2019
[Oral cavity squamous cell carcinoma also occurs in children]
Abstract:
Squamous cell carcinoma in the head and neck area is rare in children and constitutes only 2% of malignancies. Between October 2019 and December 2020, 3 young, male patients presented at the Princess Máxima Centre for Paediatric Oncology with squamous cell carcinoma of the oral mucosa. All 3 had complaints of increasing, painful swelling in the oral cavity for weeks to months prior to the diagnosis. They had no risk factors for developing an oral malignancy and blank medical histories. In all 3 cases, there was a long delay preceding the diagnosis and the diagnosis was made at an advanced stage. Although rare, primary squamous cell carcinoma of the oral cavity can also occur in children.
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