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Updated: Aug 29, 2025

A Multicenter MRI Protocol for the Evaluation and Quantification of Deep Vein Thrombosis
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A Multicenter MRI Protocol for the Evaluation and Quantification of Deep Vein Thrombosis

Published on: June 2, 2015

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Diagnosis and treatment of thrombotic microangiopathy

Gemma L Thompson1,2, David Kavanagh1,2

  • 1Complement Therapeutics Research Group, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.

International Journal of Laboratory Hematology
|September 8, 2022
PubMed

Insights

Thrombotic microangiopathy (TMA) involves low platelets, red blood cell destruction, and organ damage. Recent research has led to targeted treatments, improving outcomes for this serious condition.

Area of Science:

  • Hematology
  • Nephrology
  • Pathophysiology

Background:

  • Thrombotic microangiopathy (TMA) presents with thrombocytopenia, microangiopathic hemolytic anemia, and end-organ damage.
  • Kidney involvement is frequent due to susceptibility to endothelial damage and microvascular occlusion.
  • TMAs necessitate prompt evaluation, diagnosis, and treatment due to high morbidity and mortality.

Purpose of the Study:

  • To review the clinical presentations of TMAs.
  • To discuss the underlying pathogenesis of TMAs.
  • To outline diagnostic tests and treatments for TMAs.

Main Methods:

  • Literature review of thrombotic microangiopathy.
  • Synthesis of recent advancements in TMA pathogenesis.
  • Compilation of diagnostic and therapeutic strategies for TMAs.

Main Results:

  • TMAs exhibit diverse clinical presentations based on underlying pathophysiology.
  • Advances in understanding TMA pathogenesis have enabled targeted therapies.
  • Effective management relies on timely diagnosis and appropriate treatment initiation.

Conclusions:

  • This review provides a comprehensive overview of TMAs.
  • Understanding TMA pathophysiology is key to developing effective treatments.
  • Targeted therapeutics have significantly improved patient outcomes in TMAs.
Keywords:
STEC-HUShaemolytic uraemic syndromethrombotic microangiopathythrombotic thrombocytopenic purpura

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