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Microfabrication of Implantable Optics Integrated in a Microstructured Imaging Window for Advanced In Vivo Imaging
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An Optically Controlled Virtual Microsensor for Biomarker Detection In Vivo.

Tiange Zhang1, Shuai Wu1, Haifeng Qin1

  • 1Institute of Nanophotonics, Jinan University, Guangzhou, 511443, China.

Advanced Materials (Deerfield Beach, Fla.)
|September 8, 2022
PubMed
Summary
This summary is machine-generated.

A novel optically controlled virtual microsensor (OCViM) enables noninvasive, real-time in vivo biomarker detection. This technique precisely manipulates fluorescent nanoprobes for multipoint analysis, advancing thrombus research and drug evaluation.

Keywords:
biomarkersfluorescence imagingnanoprobesoptical manipulationthrombus

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Area of Science:

  • Biomedical Engineering
  • Optical Physics
  • Molecular Imaging

Background:

  • Current in vivo biomarker detection methods face challenges with invasiveness and probe control.
  • Needle-type microelectrodes and exogenous contrast agents have limitations in real-time analysis.
  • There is a need for advanced techniques offering precise, noninvasive control over biosensing probes.

Purpose of the Study:

  • To develop a novel technique for noninvasive, real-time in vivo biomarker detection.
  • To introduce the optically controlled virtual microsensor (OCViM) for precise nanoprobe manipulation and biosensing.
  • To demonstrate the application of OCViM in studying thrombus progression and evaluating antithrombotic drugs.

Main Methods:

  • Integration of a specially shaped laser beam (virtual handle) with fluorescent nanoprobes (sensor tip).
  • Utilizing the laser beam for programmable trapping, manipulation, and fluorescence excitation of nanoprobes.
  • Achieving noninvasive, active control of nanoprobes for multipoint detection at sub-micrometer resolution.

Main Results:

  • Demonstrated fully active, noninvasive control of nanoprobes in vivo.
  • Enabled multipoint biomarker detection with sub-micrometer resolution.
  • Successfully studied biomarker overexpression and heterogeneous distribution in zebrafish thrombus.
  • Utilized OCViM for the evaluation of antithrombotic drugs.

Conclusions:

  • OCViM offers a powerful new tool for real-time, in vivo biomarker analysis.
  • The technique overcomes limitations of current invasive methods and provides active probe control.
  • OCViM facilitates detailed mechanism studies of thrombus progression and drug efficacy evaluation.