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Differential sensitivity to bicuculline in three inbred mouse strains
Brain Research Bulletin
|May 1, 1987
Summary
Different mouse strains exhibit varying susceptibility to bicuculline-induced seizures. C3H and DBA strains are more prone to seizures and epileptiform activity than C57BL/6 mice.
Area of Science:
- Neuroscience
- Pharmacology
- Genetics
Background:
- Inbred mouse strains are valuable models for studying neurological disorders.
- Bicuculline is a known convulsant used to induce seizures and epileptiform activity in research settings.
Purpose of the Study:
- To investigate the differential susceptibility of three inbred mouse strains (DBA/2Ibg, C57BL/6Ibg, and C3H/2Ibg) to bicuculline-induced seizures.
- To compare bicuculline-induced epileptiform activity in hippocampal slices across these strains.
Main Methods:
- In vivo assessment of seizure onset and tonic seizure latency following bicuculline administration.
- In vitro electrophysiological recordings of CA1 pyramidal cell layer activity in hippocampal slices exposed to bicuculline.
Main Results:
- Strain susceptibility to seizure onset: C3H = DBA > C57BL/6.
- Strain sensitivity to bicuculline's effects on tonic seizure latency and hippocampal epileptiform activity: C3H > DBA = C57BL/6.
Conclusions:
- Mouse strain differences significantly impact susceptibility to bicuculline-induced seizures and epileptiform activity.
- The mechanisms underlying in vivo tonic seizures and in vitro hippocampal epileptiform activity induced by bicuculline may share similarities.